摘要
目的 :探讨手术切除的青年原发性肺癌的临床特点及预后的相关性。方法 :对 1978年 1月至 1996年12月手术切除的 92例 4 0岁以下原发性青年肺癌的性别、年龄、症状、诊断、治疗及预后等临床特点进行统计分析。结果 :男 71例 ,女 2 1例 ,男女之比为 3.38∶1。组织学类型中鳞癌 34例 (37% ) ,腺癌 30例 (33% ) ,小细胞癌 2 6例(2 8% ) ,大细胞癌 2例 (2 % )。TNM分期Ⅰ期 30例 ,Ⅱ期 30例 ,Ⅲ期 32例。肺叶切除 5 4例 (5 9% ) ,全肺切除 36例(39% ) ,肺楔形切除 2例 (2 % )。本组术后 5年生存率为 4 6 % (42 / 92 ) ,同期手术切除的 4 0岁以上肺癌组的 5年生存率为 34% (2 88/ 838) ,两组间差异显著 (P <0 .0 5 )。鳞癌、腺癌、小细胞癌、大细胞癌的 5年生存率分别是 6 8%、30 %、38%、0 % ,其中鳞癌的 5年生存率显著高于腺癌 (P <0 .0 1)和小细胞癌 (P <0 .0 5 ) ,腺癌与小细胞癌之间的5年生存率无显著差异。 5年生存率Ⅰ期为 6 3% ,Ⅱ期为 5 3% ,Ⅲ期为 2 2 % ,Ⅰ期与Ⅱ期之间无显著差异 ,Ⅰ期与Ⅲ期之间差异非常显著 (P <0 .0 1) ,Ⅱ期与Ⅲ期之间差异显著 (P <0 .0 5 )。结论 :青年肺癌男性明显多于女性。组织学类型中鳞癌比例最高 ,但与腺癌、小细胞癌相比较无显著差异性。青年肺癌的术后 5年生存率显?
Objective: Our aim was to investigate the correlation of clinical features and prognosis of surgical treatment for lung cancer in young patients. Methods: Ninety two young patients(≤40 years old) with primary lung carcinoma underwent surgical treatment from Jan 1978 to Dec 1996. We statistically analyzed the sex distribution, age, symptoms, diagnosis, treatment, and prognosis. Results: The ratio of men to women patients was 3.38∶1. Among them there were 34 cases of squamous carcinoma (37%), 30 cases of adenocarcinoma (33%), 26 cases of small cell lung cancer (28%), and 2 cases of large cell carcinoma (2%). According to TNM staging method , 30 cases were at stage I, 30 at stage II, 32 at stage III. Fifty four patients received lobectomy (59%),36 received pneumonectomy (39%),and 2 received wedge shaped resection(29%).The overall postoperative 5 year survival rate was 46%(42/92). The 5 year survival rate in patients older than 40 during the same period was 34%,with a very significant difference (P<0.01). The 5 year survival rates in squamous carcinoma , adenocarcinoma, small cell lung cancer and large cell lung cancer were 68%,30%,38%, and 0, respectively. The 5 year survival rate in squamous carcinoma was higher than that in adenocarcinoma(P<0.01) and small cell lung cancer(P<0.05). No significant difference of the 5 year survival rate was found between adenocarcinoma and small cell lung cancer. The 5 year survival rates were 63% in TNM stage I, 53% in stage II , 22% in stage III. No statistical difference existed between stage I and II, but very significant difference existed between stage I and III (P<0.01), and significant difference between stage II and III (P<0.05). Conclusion: The number of man in patients was obviously higher than women. Squamous carcinoma accounted for the most part in this study, with no significant difference when comparing with adenocarcinoma and small cell lung cancer. The postoperative 5 year survival rates in the young patients was 46%, which was higher than that in patients older than 40 during the same period. The patients with squamous carcinoma had good prognosis, while the prognosis of patients with cancers in stage III are not so good.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2002年第2期134-136,共3页
Journal of China Medical University
关键词
青年
肺癌
外科治疗
young patients
lung cancer
surgical treatment
