摘要
目的研究纹状体边缘区与脑内其他与学习记忆有关脑区间的关系。方法高频刺激穿通纤维-齿状回通路在海马诱发长时程增强(LTP),观察海人藻酸毁损纹状体边缘区后对海马LTP的影响。结果高频刺激穿通通路后,正常组和盐水对照组的群体峰电位幅度显著增加;毁损组动物在高频刺激后,群体峰电位增加幅度明显低于正常组和盐水对照组,毁损组的兴奋性突触后电位也明显低于正常组和盐水对照组。表明毁损边缘区后海马LTP明显降低。结论毁损纹状体边缘区后对海马LTP的形成有一定影响。
Objective To investigatetherelationshipbetweenthemarginaldivision(MrD)of thestriatumandotherbrain regionsassociatedwithlearningandmemory.Methods Long-termpotentiation(LTP)was inducedby high-frequency stimulationof theperforantpath-dentategyrus,andchangesin hippocampalLTPafterdestructionof themarginaldivision withkainicacidwereobserved.Results High-frequencystimulationof theperforantpathproducedsignificantincreasesinthe peakamplitudesof thepopulationspike(PS)in normalratsandthosereceivingsalinetreatment.In ratswithdamagedMrD,theincreasein PS andtheexcitatorypostsynapticpotentialwerelessobviouscomparedwithnormalor saline-treatedrats,indicatingthattheLTPof thehippocampuswasattenuatedby damageof theMrD.Conclusion Damageof theMrDimpacts theLTPformationinthehippocampus.
出处
《第一军医大学学报》
CSCD
北大核心
2002年第2期132-133,136,共3页
Journal of First Military Medical University
基金
国家自然科学基金(39770250)
广东省科学基金(99050)
关键词
长时程增强
海人藻酸
纹状体
边缘区
学习
记忆
long-termpotentiation
kainicacid
corpusstriatum
marginaldivision
learning
memory
