摘要
采用硫酸镁负荷量疗法治疗癫痫持续状态 (SE) 2 0例 ,并与同期采用常规综合治疗的 2 4例作对照观察。结果 :常规治疗组死亡 6例 ,症状控制时间平均为 10 .4h,在症状控制后 2 4h和 72 h血中神经特异性烯醇化酶(NSE)平均为 2 9.98± 6 .87μg/ L 和 2 6 .6 4± 5 .45 μg/ L,脑脊液 NSE平均为 34 .2 0± 7.5 2 μg/ L 和31.70± 6 .34 μg/ L。硫酸镁组死亡 1例 ,症状平均控制时间为 6 .1h(与常规治疗组比较 ,P<0 .0 5 ) ,在症状控制后2 4h和 72 h血 NSE平均为 16 .70± 3.2 8μg/ L 和 11.2 4± 5 .72 μg/ L,与常规治疗组比较均 P<0 .0 1。脑脊液 NSE平均为 18.6 0± 6 .12 μg/ L 和 13.80± 6 .12 μg/ L,与常规治疗组比较均 P<0 .0 5。认为硫酸镁负荷量给药治疗 SE可显著降低病死率 ,缩短症状控制时间 ,明显减轻脑损害。
cases of status epilepsy were treated with a large dose of magnesium sulfate,and compared with 24 cases of routine systemic methods. The result was that in the group of routine therapy,6 patients were died,the time of the symptom being controlled was mean of 10.4h,the blood HSE were mean of 29.98±6.87μg/L and 26.64±5.45μg/L in 24 hours and 3 days after the symptoms were controlled.The NSE in CSF were 34.2±7.52μg/L and 31.70±6.34μg/L respectively.Whereas in the group of magnesium sulfate,1 patient was died,the time of the symptom being controlled was 6.1h,the blood HSE were 16.7±3.28μg/L and 11.24±5.72μg/L.The NSE in CSF were 18.6±6.12μg/L and 13.8±6.12μg/L.We believed that the method of a large doe of magnesium sulfate could decrease the death rate,shorten the time of the symptom being controlled and abate the brain damage obviously.
出处
《山东医药》
CAS
北大核心
2002年第8期13-15,共3页
Shandong Medical Journal
