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α_1肾上腺素受体对豚鼠心肌细胞延迟整流钾电流的调控 被引量:1

Modulation of α1 adrenergic receptor on ventricular myocytes of guinea pig
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出处 《中华心律失常学杂志》 2002年第2期102-102,共1页 Chinese Journal of Cardiac Arrhythmias
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  • 1Vandenberg JI, Perry MD, Perrin MJ, et al. hERG K^+ channels : structure, function, and clinical significance [ J ]. Physiol Rev, 2012,92 : 1393-1478.
  • 2Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia [ J]. Nature ,2006,440:463-469.
  • 3Brodde OE, Michel MC. Adrenergic and musearinic receptors in the human heart[J]. Pharmacol Rev,1999,51:651-690.
  • 4Harmati G, Bamyasz T, Barandi L, et al. Effects of β-adrenoceptor stimulation on delayed rectifier K^ + currents in canine ventricutar cardiomyocytes [ J ]. Br J Pharmaco1,2011,162 : 890- 896.
  • 5Karle CA, Zitron E, Zhang W, et al. Rapid component IKF of the guinea-pig cardiac delayed rectifier K^+ current is inhibited by β1- adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways [ J ]. Cardiovasc Res ,2002,53 : 355-362.
  • 6Thomas D,Wu K, Wimmer AB, et al. Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by ctlA- adrenoceptors[ J]. J Mol Med (Bed) ,2004,82:826-837.
  • 7Wang S,Xu D J, Cai Jb, et al. Rapid component IKr of cardiac de- layed rectifier potassium currents in guinea-pig is inhibited by cL1- adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways [ J ]. Eur J Pharmaco1,2009,608 : 1-6.
  • 8Thomas D, Kiehn J, Katus H, et al. Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium cur- rent, IKr, and the underlying bERG ion channel [ J ]. Basic Res Cardio1,2004 ,99 :279-287.
  • 9Thomas D, Zhang W, Wu K, et al. Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the ehannel protein [ J ]. Cardiovasc Res, 2003,59 : 14-26.
  • 10. Coekerill SL, Tobin AB, Torrecilla I, et al. Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evi- dence for direct phosphorylation of pore forming subunits [J] J Physio1,2007,581:479-493.

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