摘要
目的 观察并发于充血性心力衰竭的心房颤动 (房颤 )伴快心室反应的患者静脉注射胺碘酮的有效性及安全性。方法 对 85例充血性心力衰竭并发房颤伴快心室反应患者 ,首次剂量给予胺碘酮 3mg/kg ,15min后无效再补半剂突击量。维持量为 6 0 0mg胺碘酮稀释于 5 0 0ml生理盐水中静脉点滴 2 4h。 结果 突击负荷量 15 0～ 30 0 (180± 37)mg ,有效率为 77 6 % ,副作用发生率为 8 2 % ,无心功能恶化。 结论 静脉注射胺碘酮治疗并发于充血性心力衰竭的房颤伴快心室反应是有效且较安全的方法。
Objective The aim of this study is to evaluate the efficacy and safety of intravenous amiodarone for atrial fibrillation with rapid ventricular response in patients with congestive heart failure.Methods Eighty-five patients with congestive heart failure and initial atrial fibrillation were included in this study.The first bolus of amiodarone was given at 3 mg/kg intravenously followed by sustained infusion of 600 mg in 24 hours if the result was not satisfactory 15 minutes after the bolus injection.The efficacy was defined as returning to sinus rhythm in 48 hours or the ventricular response decreases to below 100 bpm after initiating amiodarone.Results The average loading dose was 150～300(180±37) mg.Sixty-six patients returned to sinus rhythm(77.6%).Eleven patients with continous atrial fibrillation after amiodarone infusion had ventricular rate below 100 bpm.Possible side effects were observed in 7 patients.Atrio-ventricular Wenchobech block was observed in one patient,hypotension in 1 and nausea and vomiting in 2.Conclusion Amiodarone is safe and effective in management of atrial fibrillation with fast ventricular response in patients with congestive heart failure.
出处
《中华心律失常学杂志》
2002年第2期76-77,共2页
Chinese Journal of Cardiac Arrhythmias
