摘要
目的 :探讨不同透析器复用方式对各种连续性肾脏替代疗法 (CRRT)模式溶质清除率的影响。 方法 :采用体外试验 ,聚砜膜F60透析器共分三组 ,A组为首次使用的透析器 ,B组为用次氯酸钠加甲醛复用的透析器 ,C组为单用甲醛复用的透析器 ,分别行连续性静脉 静脉血液滤过 (CVVH) ,连续性静脉 静脉血液透析 (CVVHD)及连续性静脉 静脉血液透析滤过 (CVVHDF) ,并同时测定尿素、肌酐、VitB1 2 、菊粉的清除率。 结果 :不同CRRT方式对小分子物质的清除率在三组间无显著差异 ,对中、大分子物质的清除率 ,CVVH ,CVVHDF方式下C组较A组显著下降 (P <0 0 5) ,CVVHD方式下 ,三组间无显著差异。 结论 :CRRT时透析器复用要加入漂白剂成份才能确保中。
Objective:To evaluate the effects of different methods of hemodialyzer reuse on solute clearance in various continuous renal replacement therapy (CRRT) modes. Methodology:In vitro model,eighteen polysulfone hemodialyzer(F60)were divided into three groups.Group A was new hemodialyzers,group B was bleach/formaldehyde reprocessing hemodialyzers,and group C was only formaldehyde reprocessing ones.Methods of CRRT were continuous venous venous hemofiltration(CVVH),continuous venous venous hemodialysis (CVVHD),and continuous venous venous hemodialysis and filtration(CVVHDF).Solute clearances of urea,creatinine,vitamine B 12 ,inulin were determined by routine methods. Results:There was no significant difference of the urea and creatinine clearance among three groups in any methods of CRRT.In group C,vitamine B 12 and inulin clearance were significantly lower than that in group A( P <0 05)with CVVH and CVVHDF,however,those clearance did not change significantly among three groups with CVVHD. Conclusion:Bleach reprocessing is necessary for ploysulfone dialyzers to ensure the maintenance of larger solute clearances in CRRT.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
2002年第2期138-141,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
上海市科委学科带头人计划资助编号(99XD14 0 2 1)
