摘要
目的研究 8 (N ,N 二乙铵 ) n 辛基 3,4 ,5 三甲氧基苯甲酸酯 (TMB 8)对谷氨酸诱导神经细胞DNA损伤的影响。方法用谷氨酸诱导培养的大鼠皮层神经细胞DNA断裂 ,观察TMB 8对神经细胞DNA断裂和线粒体功能的影响。结果TMB 8能明显减轻谷氨酸诱导的大鼠皮层神经细胞DNA断裂并能改善线粒体功能。结论TMB 8具有抑制神经细胞DNA损伤的作用 ,其机制可能与其降低细胞内游离钙。
PurposeThe aim is to investigate the effect of 8 ( N,N diethylamino)octyl 3,4,5 trimethoxybenzoate on neuron DNA injury.MethodsDNA injury of cultured cortical neuron induced by glutamate was used to observe the effect of TMB 8 on DNA fragment and mitochondrial function.ResultsTMB 8 could obviously inhibit neuron DNA fragment and improve mitochondrial function.ConclusionTMB 8 can inhibit neuron DNA injury through decreasing [Ca 2+ ]i.improving mitochondrial function and reducing glutamate oxidative toxicity
出处
《中国生化药物杂志》
CAS
CSCD
2002年第2期64-66,共3页
Chinese Journal of Biochemical Pharmaceutics
