摘要
目的 观察多系统萎缩脑和脊髓内少突胶质细胞包涵体并评估其诊断意义。方法 应用Gallyas Braak银染色法研究 4例经临床和传统病理方法诊断的多系统萎缩的脑和脊髓标本 ,以 8例运动神经元病的脑和脊髓 ,6例无神经系统症状和病理改变的同龄人脑标本作对照。结果 4例病例中 3例的脑和脊髓白质发现少突胶质细胞包涵体 ,该包涵体位于少突胶质细胞胞质内 ,呈半月形、镰刀形、火焰形。主要分布于脑桥、小脑、苍白球 壳核、延髓白质纤维束 ,脊髓外侧束 ,且与髓鞘变性脱失的分布一致。另有 1例临床缺乏植物神经症状 ,黑质和脊髓中间外侧柱细胞无明显病变者 ,其脑和脊髓白质未观察到这种包涵体。所有对照病例的脑和脊髓白质内也未发现少突胶质细胞包涵体。结论 少突胶质细胞包涵体是散发性多系统萎缩特异性较高的病理标志 。
Objective To investigate the oligodendroglial cytoplasmic inclusion (OCI) in the central nervous system of multiple system atrophy (MSA) and to evaluate its roles in pathologic diagnosis of MSA.Methods Modified Gallyas Braak staining was used to investigate tissue samples of the brain and the spinal cord of 4 cases with MSA, which were previously diagnosed by clinical and routine pathologic methods. Eight cases with motor neuron disease and 6 cases without nervous system disease were used for control study.Results OCIs were demonstrated by Gallyas barrak method in the white matter of the brain and the spinal cord of 3 cases with MSA. They look like sickle , semilunar , and flame shaped. Their main distributions were transverse fibers of the basis pontine, the white matter of the cerebellum, striatopallidal fibers and lateral column of the spinal cord. While OCIs were not found in the brain and the spinal cord of one case without typical clinical features and pathologic findings. Nor did all of the control cases.Conclusions OCIs may be regarded as pathologic marker of the sporadic forms of MSA. It also suggests that OCIs are related to degenerative process of myelinated fibers in MSA.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2002年第2期99-102,共4页
Chinese Journal of Neurology
基金
国家九七三课题资助项目 (G2 0 0 0 0 5 70 )
关键词
少突神经胶质
包涵体
多系统萎缩
诊断
Oligodendroglial
Inclusion bodies
Multiple system atrophy
