摘要
目的 :探讨原发性高血压盐敏感者左心室重量与钠代谢的关系。方法 :对 71例原发性高血压患者 (原发性高血压组 )和 2 3例血压正常者 (正常对照组 )用静脉盐水负荷法确定盐敏感性 ,用超声法测量左心室重量指数 (LVMI) ,并测定 2 4h尿钠量及红细胞钠含量。结果 :①原发性高血压组和正常对照组盐敏感者LVMI均大于盐不敏感者 ,有显著性差异 (P <0 0 1) ,原发性高血压组盐敏感者左心室肥厚的检出率高于盐不敏感者 ,有显著性差异 ( 2 4 3%vs .5 8% ,P <0 0 5 ) ;② 2组盐敏感者盐负荷后红细胞钠含量显著增加 ,有显著性差异 (P <0 0 1) ,而盐不敏感者变化不明显 (P >0 0 5 ) ;③原发性高血压组患者的LVMI与 2 4h尿钠量及红细胞钠含量均呈显著正相关性 (P <0 0 1) ;逐步回归分析表明 ,红细胞钠含量是原发性高血压患者左心室肥厚的一个独立危险因素。结论 :高血压盐敏感者左心室重量明显大于盐不敏感者 ,提示高血压左心室肥厚的发生除血压等因素外 。
Objective:To investigate the change of left ventricular mass and its relationship with diet sodium intake as well as erythrocytic sodium content in salt sensitive hypertensive patients. Methods:Seventy-one adult hypertensive patients and 23 normotensive controls were enrolled in the study.Salt sensitivity was determined by acute intravenous salt water loading according to Sullvan's criteria.M-mode echocardiography was performed for the measure ment and calculation of left ventricular mass index(LVMI).24-hour urinary sodium and erythrocytic sodium content were measured in all patients. Results:①Compared with non-salt sensitive(NSS),salt sensitive(SS)subjects,either hypertensive or normotensive,exhibi- ted an increased LVMI(p<0.01).Left ventricular hypertrophy(LVH)was present in 9 of 37(24.3%) SS hypertensive patients and only in 2 of 34(5.8%)NSS hypertensives;②Erythrocytic sodium content increased significantly in SS hypertensives,but no distinct change(p>0.05) in NSS after salt water loading(p<0.01),③LVMI was positively correlated with diet sodium intake(γ=0.44,p<0.01)and erythrocytic sodium content (γ=0.49,p<0.01)in hypertensives,especially in SS patients;cox regression analysis showed erythrocytic sodium content was an independent risk factor to LVH. Conclusions:Compared with non-salt sensitive,salt sensitive hypertensives show greater left ventricular mass,which,in addition to blood pressure,was positively related to the abnormal sodium metabolism.
出处
《中国循环杂志》
CSCD
北大核心
2002年第2期99-101,共3页
Chinese Circulation Journal
