摘要
测定了单独使用 3种喹诺酮类抗生素及与外输泵抑制剂利血平 (2 0 μg/ml)结合使用 ,对临床分离的 2 2株凝固酶阴性葡萄球菌的MIC。结果表明 ,利血平使个别敏感菌株和中低度耐药菌株的MIC降低 ,说明其存在外输泵介导的耐药表型 ;而对喹诺酮高度耐药菌株的MIC却没有受到影响 ,一些菌株的MIC甚至变大。另外 ,利血平对亲水性喹诺酮影响较大 。
The activities of 3 quinolones or quinolone plus efflux pump inhibitor(reserpine) were tested against 22 clinical isolates of coagulase negative staphylococci Reserpine(20 μg/ml) decreased MIC of hydropilic quinolone against susceptible coagulase negative staphylococci and median or lowly resistant coagulase negative staphylococci This indicates a major contribution of efflux pumps to the resistance phenotype in some strains No effect of reserpine on the activities of the quinolones against highly resistant S. aureus were observed Unexpectedly, the combination of reserpine and quinolone produced an increase of MIC in one strain Reserpine produced a bigger decrease in the MIC of hydrophilic quinolones compared to hydrophobic ones
出处
《广州医药》
2002年第3期49-51,共3页
Guangzhou Medical Journal
