摘要
观察 1,6 二磷酸果糖对冠心病心力衰竭患者的血液动力学影响 ,以评价其对心力衰竭的作用。 4 7例冠心病合并心力衰竭患者分别在 1,6 二磷酸果糖静脉滴注前、滴注后 30min和滴注后 12 0min测定心率、平均动脉压 ,使用超声心动图测定射血分数、每搏输出量、每搏指数、心输出量、心指数及缩短分数。结果发现 ,治疗前后心率和平均动脉压均无显著性改变。除射血分数外 ,心功能各指标治疗后均较治疗前明显增高 (P <0 .0 5 ) ,且滴注后12 0min时比滴注后 30min时更为明显。结果提示 ,静脉滴注 1,6 二磷酸果糖能改善冠心病心力衰竭患者的血液动力学指标 ,改善心功能 ,具有正性肌力作用 ,但不增加心肌耗氧量。
Aim To study the hemodynamic effects of fructose 1,6 diphosphate (FDP) in patients with coronary artery disease (CAD) complicated with chronic heart failure (CHF). Methods 10 g FDP was intravenously infused in 47 cases of CAD with CHF. Heart rate (HR), mean arterial pressure (MAP), ejection fraction (EF), stroke volume (SV), stroke index (SI), cardiac output (CO), cardiac index (CI) and fractional shortening (FS) were measured before, 30 min and 60 min after the infusions. Results The results indicated that apart from EF 30 min after versus before the infusions, all of the cardiac function parameters dramatically increased after the treatment while the augmentations were larger in 120 min than in 30 min after the treatment. Conclusions FDP intravenous administration in patients with CAD complicated with CHF could improve the hemodynamic status and cardiac function. The drug possessed positive inotropic property but would not increase O 2 consumption.
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第2期169-170,共2页
Chinese Journal of Arteriosclerosis
关键词
果糖二磷酸
心力衰竭
血液动力学
冠状动脉疾病
Fructosediphosphates
Chronic Heart Failure (CHF)
Hemodynamics
Coronary Diseases
