摘要
为观察守宫水蛭组方是否对大鼠局灶性脑缺血再灌注损伤有保护作用 ,将 4 8只Wester大鼠随机分为偏瘫康大、小剂量组、模型组、假手术组、西比灵及华佗再造丸阳性对照组 ,分别给予一周药物后用尼龙线栓塞大脑中动脉 ,栓塞 1h后再通 ,制做局部脑缺血再灌注损伤模型 ,于手术后分别对大鼠行为障碍进行术后评分 ,断脑取血测血清乳酸脱氢酶和肌酸激酶含量 ,取手术侧脑测定含水量及脑组织Na+ 、K+ 、Ca2 + 和Mg2 + 含量。结果发现 ,脑缺血再灌注损伤 6h后 ,大鼠行为障碍术后评分增高 ,出现脑水肿 ,Na+ 含量增高 ,血清乳酸脱氢酶和肌酸激酶含量也明显升高 ;而预先服用不同剂量的守宫水蛭组方均可明显逆转大鼠脑缺血再灌注损伤的上述变化。
Aim Investigate the Protective Effect of Shou-Gong Shui-Zhi Composition on Regional Cerebral Ischemia Reperfution Injury in Rats. Methods Acute cerebral ischimia reperfution injury model in the rat was established by introducing nylon suture into middle cerebral artery (MCA) for occlusion and then taking out the nylon suture. The behavior obstacle marks of rats was studded, and the water contents in brain,LDH and CK activity in serum,Na +, K +,Ca 2+ , Mg 2+ levels of cerebral tissue was measured. Results Shou-Gong Shui-Zhi Composition can enhance the behavior obstacle marks of rats, decrease contents of H 2O, LDH, CK activity and Na + levels after ischemia reperfution. Conclusion Shou-Gong Shui-Zhi Composition could protect brain ischemia reperfution injury
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第2期122-124,共3页
Chinese Journal of Arteriosclerosis
基金
湖南省卫生厅中医药科研基金 (982 2 1)
关键词
守宫水蛭组方
脑缺血
再灌注损伤
疾病模型
动物
保护作用
Shou-Gong Shui-Zhi Composition
Cerebral Ischemia
Reperfusion Injury
Disease Models, Animal
Protective Effect
