摘要
目的 :观察红霉素肠溶胶囊治疗呼吸道感染的临床疗效、安全性。方法 :80例轻中度呼吸道感染患者用红霉素肠溶胶囊 5 0 0mg ,bid ,疗程 5～ 7d。观察治疗前后临床症状与体征 ,记录可能与使用该药相关的各种不良反应。结果 :痊愈 45例 ,显效 2 6例 ,进步 7例 ,无效 2例 ,痊愈率与总有效率分别为 5 6 .3%和 88.8%。共分离出 16株细菌 ,其中11株细菌敏感 ,4株中介度 ,1株耐药。细菌清除率 93.7%。轻度恶心、上腹部不适 4例 ,大便次数增加 2例 ,未经特殊处理 ,症状消失。另 2例恶心、呕吐 ,1例出现严重腹泻 ( 7次·d 1 ) ,不能耐受治疗而停药。不良反应总发生率 10 .8%。 48例治疗前后肝、肾功能均未见异常 ,5 3例治疗前后血、尿常规检查正常。结论 :红霉素肠溶胶囊治疗呼吸道感染有效率和细菌清除率高 ,疗效显著 ,安全。
Objective:To evaluate the clinical therapeutic effect and safety rate of enteric coated capsules of erythromycin in the treatment of respiratory tract infections. Methods:80 patients with mild or moderate respiratory tract infection were treated with erythromycin in enteric coated capsule at a dosage of 500 mg b.i.d PO for 5～7 days. Clinical symptoms and signs before and after the treatment as well as adverse reactions to the remedy were kept under observation. Results:Of the 80 patients, 45 were cured, 26 got dramatic effects, 7 showed improvement, while 2 failed to respond to the medication. The cure rate and total effective rate were 56.3%(45/80) and 88.8%, respectively. Of the 16 bacteria strains isolated, 11 were found to be sensitive, 4 moderately sensitive, and 1 resistant to erythromyein. The eradication rate of bacteria was 93.7%. 4 patients experienced mild nausea and epigastric discomfort, 2 others had increased bowel movements. These symptoms, however, disappeared subsequently without any treatment. 2 other patients complained of nausea and vomiting, while one of them suffered form severe diarrhea(7 times·d 1 ) and the medication was therefore suspended. The total incidence of adverse reactions was 10.8%(9/83). No abnormalities were found by liver and renal function tests in 48 patients before and after the treatment. Blood and urine routine tests in 53 patients before and after the treatment showed no abnormalities as well. Conclusion:Erythromycin in enteric coated capsules is effective and safe in the treatment of respiratory tract infections, with a high eradication rate of bacteria.
出处
《医药导报》
CAS
2002年第5期290-291,共2页
Herald of Medicine
关键词
红霉素肠溶胶囊
感染
呼吸道
疗效观察
Erythromycin, Enteric coated capsule
Respiratory tract infection
Evaluation of curative effect
