摘要
目的 :探讨壳聚糖吸附澄清法能否代替乙醇沉淀法用于咳喘宁口服液的澄清工艺。方法 :壳聚糖用于咳喘宁口服液的澄清 ,并与部颁标准的醇沉制备方法比较 ,通过对盐酸麻黄碱、甘草酸铵、盐酸罂粟碱进行定性和对盐酸麻黄碱进行含量测定 ,并进行了稳定性实验比较。结果 :壳聚糖吸附澄清法与醇沉法均能使药液澄清 ,前者更能保留药液中的有效成分 ,又能保证制剂的稳定性。结论
Objective: To find out a new clarification process of Kechuanning Oral Liquid by chitosan, and to compare with the process with ethanol sediment. Methods: Glycyrrhizinate, papaverine hydrochlorid were qualitatively analysed and ephedrine hydrochloride was quantitatively determined in the two processes. Stability of the two preparations were compared. Results: Both the processes by chitosan and by ethanol have clearing action the former reserved more effective components than the latter. Conclusion: the process by chitosan can substitute for process by ethanol sediment in production of Kechuaming Oral Liquid.
出处
《中成药》
CAS
CSCD
北大核心
2002年第5期337-339,共3页
Chinese Traditional Patent Medicine
关键词
壳聚糖
咳喘宁口服液
纯化除杂
chitosan
Kechuanning Oral Liquid
clarification
