摘要
目的:评价比较CTF和CAF方案治疗中晚期或转移性乳腺癌的疗效和不良反应。方法:根据GCP指导原则开展多中心临床协作研究。治疗组:THP40mg/m2,静脉注射d1,5-FU500mg/m2,静脉滴注d1、8,CTX500mg/m2,静脉注射d1、8;对照组:ADM40mg/m2,静脉注射d1,5-FU500mg/m2,静脉滴注d1、8,CTX500mg/m2,静脉注射d1、8,21天为1周期,接受2周期化疗后评价。结果:共收治100例,治疗组77例,对照组23例。治疗组CR8例,PR40例,有效率62.3%;对照组CR1例,PR11例,有效率52.2%。THP的有效率高于ADM,但无统计学差异(P>0.05)。两组不良反应中血液不良反应相似,而脱发、皮肤不良反应和心电图指标改变,治疗组明显低于对照组,有统计学差异,其余指标差异无显著性。结论:THP的有效率与ADM相似,但脱发、皮肤不良反应及心电图改变低于ADM,可代替ADM在临床上予以应用,尤其适用于老年患者及年轻女性。
Objective:To evaluate the efficacy and toxicity of CTF and CAF regimen in the treatment of advanced and metastatic breast cancer.Methods :One hundred cases of breast cancer were randomly divided into group A and group B(group A:THP40mg /m 2 iv d1;5-FU500mg /m 2 iv drip,d1?8;CTX500mg /m 2 iv drip d1?8;group B:ADM40mg /m 2 iv d1;5-FU500mg /m 2 iv drip,d1?8;CTX500mg /m 2 iv drip,d1?8.Results:The overall response rate of Group A(77cases)was62.3%,while that of group B was52.2%.There was no significant dif-ference between these two groups.The incidence of adverse reactions in the treated group(alope-cia,skin and cardiac toxicity)was significantly lower than that in the control group(P<0.05).Conclusion:THP-containing regimen is an active regimen with relatively low toxicity than ADM,THP and it can be widely used clinuically.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第5期352-355,共4页
Chinese Journal of Clinical Oncology
