摘要
二级雄性Wistar大鼠 35只 ,随机分为 7组 ,每组 5只 ,1组为空白对照 ,其余 6组为辐照组以 98.5 5W cm2 的脉冲微波辐照动物 ,辐照后 1、6、2 4h和 7、1 4、2 8d分别采血 ,用Coulter JTIR全自动生化仪进行测定 ,所有数据经Spss8.0统计软件处理 .辐射后 1h,CRE明显增高 (P <0 .0 1 ) ,而TP、ALB、AST、LD1、CK、ALP及CHOL均明显降低 (P <0 .0 5 ) ;辐射后 6h,其CRE明显增高 (P <0 .0 5 ) ,而TP、ALB、LD1、ALP及CHOL均明显降低 (P<0 .0 5 ) ;辐照后 2 4h,其ALT、GLU、BUN、CRE、AST、LD和HBDH明显升高 (P <0 .0 5 ) ,而ALB和CHOL则明显降低 (P <0 .0 5 ) ;辐照后 7d,其ALT、ALB、GLU、CRE、CK MB和GGT明显升高 (P <0 .0 5 ) ,而BUN和LD1则明显降低 (P <0 .0 5 ) ;辐照后 1 4d ,其CRE、LD、CK MB和GGT明显升高 (P <0 .0 5 ) ,而TP和CHOL则明显降低 (P <0 .0 1 ) ;辐照后 2 8d,其ALT、TP、BUN和CRE明显升高 (P <0 .0 5 ) ,而ALB、AST、LD1、CK、ALP和CHOL则明显降低 (P <0 .0 1 ) .提示HPPMW可引起大鼠血清多种酶、蛋白及代谢产物的紊乱 ,既有早期影响 ,也表现为一定的持续效应 .HPPMW可能引起大鼠多系统。
Thirty-five male Wistar rats were randomly divided into seven groups. A control group and six HPPMW groups. HPPMW groups were irradiated by 98.55?W/cm 2 HPPMW strength 2 pulses within 5 minutes respectively, no treat to contrast group. The left ventricle blood was sarnpled at 1, 6, 24 h and 7, 14, 28 d after irradiation, and were measured by Coulter-JTIR automatic biochemical analyzer. All data was analyzed by statistical softwareSpss8.0. The results suggested that a flucturation of the biochemical indexes in rat serum could be induced by HPPMW, which showed some early stage effects and durative effects. It is inferred that HPPMW could injure many organs and systems of rats.
出处
《生命科学研究》
CAS
CSCD
2002年第1期79-83,共5页
Life Science Research
基金
军队总后勤部"十五"指令课题基金资助顶目 ( 0 1L0 2 3)
