摘要
目的 探讨抗血管自身抗体在高血压发病中的价值。方法 收集了高血压病人 15 4例以及正常血压对照 4 0例作为研究对象。以人工合成AT1受体、α1 受体胞外第二环多肽片段为抗原 ,ELISA法检测入选病人及对照组血清中的抗AT1受体、α1 受体抗体等抗血管自身抗体。分析抗血管抗体在不同高血压亚组中的差异及抗体与高血压的关系。结果 抗体阳性病人在重度及难治性高血压组明显高于一般高血压病人和正常对照组。结论 抗AT1受体和α1 受体自身抗体可能参与了高血压 ,尤其是重度高血压和难治性高血压的发病 ,检测抗AT1受体和α1 受体自身抗体有助于高血压的诊断和药物选择。
Objective To investigate the effects of the autoantibodies against vascular in the developing of hypertension. Methods 154 patients with primary hypertension and 40 normotensive patients were recruited as controls. The epitope of the 2 nd extracellular loops of type 1 angiotensinⅡ(AT1) receptor and α 1 adrenoceptor were synthesized and used as antigens to screen the autoantibodies against AT1 receptor and α 1 adrenoceptor by ELISA assay.Results The positive rate of the autoantibodies against AT 1 receptor and α 1 adrenoceptor were higher in patients with severe and refractory hypertension than in mild and moderate ones and normotensives.Conclusion The autoantibodies against AT1 receptor and α 1 adrenoceptor perhasp contribute to the pathogenesis of hypertension, especially in severe and refractory hypertension. To monitor the autoantibodies against AT 1 receptor and α 1 adrenoceptor might have an improtant value in the diagnosis and drug treatment.
出处
《重庆医学》
CAS
CSCD
2002年第5期390-391,393,共3页
Chongqing medicine
基金
卫生部临床学科重点资助项目 (970 70 2 38)
