摘要
脑膜瘤在光镜上显示明显的异质性,除间叶成分外,还存在上皮成分。脑膜瘤的组织发生学还有争论。为此我们对28例脑膜瘤应用免疫组化技术显示波形蛋白(Vim)、上皮膜抗原(EMA)、低分子角蛋白(10·11)、S-100蛋白(S-100)、角蛋白(KT)和癌胚抗原(CEA)。结果表明脑膜瘤除间叶组织标志 Vim 阳性外,部分还表达上皮组织标志,证实脑膜瘤的二元分化。根据脑膜瘤的光镜形态和免疫组化结果提示脑膜瘤来源于一种区别于纤维母细胞和血管内皮细胞的特殊细胞类型,可称之为脑膜上皮细胞,具有向间叶和上皮的分化潜能。
Meningioma shows morphological heterogeneity in light microscopy.The histo-genesis of meningioma is uncertain.By the use of immunohistochemical staining(ABC and PAP methods).The distribution of Vimentin,Epithelial membrane anti-gen,Light weight cytokeratin,S-100 protein,Keratin and Carcinoembryonic antigenin 28 cases of meningiomas have been investigated.The results demonstrated that meningioma expressed the markers of both mesen-chymal and epithelial tissues.The observation that meningiomas contained both Vimentin filaments and themarkers of epithelial supported the concept of the so-called“meningothelial cell”asthe progenitor cell for menigiomas,exhibiting both epithelial and mesenchymal fea-tures.
出处
《天津医药》
CAS
1991年第3期134-136,共3页
Tianjin Medical Journal
