摘要
目的 研究巨细胞病毒 (CMV)肝炎患儿血清干扰素 α(IFN α)、白细胞介素 8(IL 8)和肿瘤坏死因子 α(TNF α)水平的变化及其临床意义。方法 应用ELISA法检测 35例CMV肝炎患儿血清中上述三种细胞因子的含量 ,并对其两两之间进行了相关性分析。结果 CMV肝炎组患儿IFN α、IL 8、TNF α的含量分别为 (770 .3± 2 0 5 .4 )ng/L、(41.9± 2 2 .5 )ng/L和 (10 33.2± 388.5 )ng/L ,非常显著高于正常对照组 (P <0 .0 1)。相关性研究发现IFN α与TNF α呈显著正相关 (r =0 .35 6 ,P <0 .0 5 )。
Objective To study the change of serum cytokines (IFN alpha, IL 8 and TNF alpha) and its clinical implication in cytomegalovirus (CMV) hepatitis children with age ranging from one month to six months.Methods The levels of IFN alpha, IL 8 and TNF alpha in 35 children with CMV hepatitis were detected by using ELISA and the correlations between them analyzed.Results The levels of IFN alpha [( 770.3 ± 205.4 ) ng/L], IL 8 [( 41.9 ± 22.5 ) ng/L] and TNF alpha were obviously higher than in the normal group.There was a positive correlation between IFN alpha and TNF alphaf( P < 0.05 ).Conclusion In the children with CMV hepatitis, the elevated serum cytokines have a close relationship to the extent of damage and the pathological change.
出处
《华中医学杂志》
2002年第2期75-76,共2页
Central China Medical Journal
