摘要
目的 :探讨充血性心力衰竭 (CHF)患者血小板活化与纤溶活性的变化。方法 :采用放免法和发色底物法测定 5 0例CHF患者 (CHF组 )及 2 0例健康人 (对照组 )血小板α 颗粒膜蛋白 (GMP 14 0 )、组织型纤溶酶原激活剂 (t PA)及其抑制物 (PAI 1)、血管紧张素Ⅱ (AgⅡ )和醛固酮 (Ald)水平。结果 :CHF组的测定值与对照组比较GMP 14 0含量、PAI 1活性、AgⅡ及Ald水平均显著升高 (P <0 .0 1) ;t PA活性显著下降 (P <0 .0 1) ;且心功能越差 ,上述改变愈明显 ;CHF组GMP 14 0含量及PAI 1活性均与AgⅡ水平呈显著正相关 (r分别为 0 .4 2 5和 0 .4 34,P均 <0 .0 1)。结论 :血小板活化及纤溶活性与心力衰竭的发生。
Aim:To study the changes of platelet activation and fibrinolytic activity in patients with congestive heart failure (CHF).Methods:The levels of platelet alphagranule membrane protein(GMP 140), tissue type plasminogen activator(t PA) and its inhibitor(PAI 1), angiotensin Ⅱ(AgⅡ), and aldosterone(Ald) were determined by using radioimmunoassay and spectrophotometric assay in 50 patients with CHF and 20 normal controls.Results:Compared with control, the levels of GMP 140,PAI 1,AgⅡ,and Ald increased significantly ( P <0.01), and t PA activity decreased significantly ( P <0.0l) in the CHF groups. And the greater these changes were, the worse the heart function was. In the CHF group, the positive correlation was showed between the levels of AgⅡ and GMP l40 ( r=0.425,P <0.01), and AgⅡ and PAI 1 ( r=0.434,P <0.01).Conclusion:The results suggest that platelet activation and fibrinolytic activity play an important role in the pathophysiologic changes of CHF.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2002年第2期213-214,共2页
Journal of Zhengzhou University(Medical Sciences)
