摘要
目的和方法：运用免疫组化技术ＳＰ法检测ＭＭＰ －９、ＴＩＭＰ－１在６８例膀胱移行细胞癌中的表达，分析它们与临床病理分级、分期的关系。旨 在探寻它们在膀胱移行细胞癌（ＴＣＣＢ）浸润、转移中的作用。结果：ＭＭＰ－９在ＴＣＣＢ中高表达， ４１／６８例阳性，阳性率为６０％。ＭＭＰ－９的表达阳性率随肿瘤分级、分期的升高而增加 （Ｐ＜０．０５）。ＴＩＭＰ－１在ＴＣＣＢ中高表达，３１／６８例阳性，阳性率为４５．５％。ＴＩＭＰ－１的 表达随肿瘤分级、分期的增加而呈下降趋势（Ｐ＜０．０５）。ＭＭＰ－９在ＴＣＣＢ的表 达与ＴＩＭＰ－１的表达经统计学分析有相关性。ＭＭＰ－９（＋）／ＴＩＭＰ－１（－）表达在浸润性或高分级 肿瘤中则比例较高，差异有统计学意义（Ｐ＜０．０５）。结论：ＭＭＰ－９和ＴＩＭＰ－ １与ＴＣＣ Ｂ的分级和分期相关，ＭＭＰ－９及ＴＩＭＰ－１的差异表达对于ＴＣＣＢ的侵袭发展发挥了重要作用。
Purpose and Methods:The expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were s tudied by SP immunohistochemistry in 68 cases of transitional cell carcinoma of bladder to investigate the relationship of the expression and clinicopathologica l parameters.Results:The expression of MMP-9 and TIMP-1 were higher in TCCB.The expression rate of MMP-9 was 60% and was elevated with grade and stage.The expre ssion rate of TIMP-1 was 45.5%.There was a inverse relationship between the expr ession rate and grade or stage.It was found that the tumors expressed MMP-9(+)/T IMP-1(-) had higher pathological stage and grade than the groups expressed MMP-9 (-)/TIMP-1(+).Conclusions:The expressions of MMP-9 and TIMP-1 be correlated with grade and stage of TCCB.The increased MMP-9 expression and decreased TIMP-1 exp ression were associated with the invasion and development of TCCB.
出处
《内蒙古医学杂志》
2002年第2期95-98,共4页
Inner Mongolia Medical Journal
