摘要
探讨中国人胰腺癌的发生与生活、饮食习惯的关系。以 4 93例确诊的胰腺癌患者作为病例组 ,10 31例年龄和性别、经济收入频数匹配的同来源非肿瘤患者为对照组 ,用病例对照研究的方法计算比值比(OR)及 95 %可信区间 (CI) ,以估计烟、酒对胰腺癌的相对危险性 ,并用t检验估计两组的体重指数差别。结果发现 ,在吸烟人群中胰腺癌的危险性上升 ,男女的OR分别为 2 3(95 %CI为 1 8～3 1)和 3 0 (95 %CI为 1 2～ 7 8) ,并且随着每天吸烟支数、吸烟年数及年支数的增加而升高 ,但随着开始吸烟年龄或戒烟年数的上升而下降。经吸烟调整后 ,男性饮酒者胰腺癌的危险性上升 ,OR为 1 7(95 %CI为 1 3～ 2 3)。男性体重指数 (BMI) ,病例组明显高于对照组(P <0 0 1) ,而女性无明显差异 (P >0 0 5 )。因此 ,男性吸烟、重度饮酒、BMI是胰腺癌的危险因素 。
The study was to analyze the relationship between the occurrence of pancreatic cancer with life style and diet habits of Chinese population. A case control study comprising of 493 histologically confirmed pancreatic cancer patients was made to compare with 1031 hospitalized non neoplastic controls matched in age, sex and economical income. The value of odds ratio(OR) and its 95% confidence interval (CI) were calculated to estimate the relative risk of smoking and alcohol consumption in cancer patients, and estimate the difference of BMI by T test. The results showed that the risk of pancreatic cancer increased among smoking groups. OR for male and female were 2 3(95%CI:1 8～3 1) and 3 0(95%CI:1 2～7 8) respectively, and it increased with increasing number of cigarets consumed eachday and number of years of smoking. However, OR showed a tendency of lowering with an increase of age of starting smoking as well as the number of years quitting. When adjusted with smoking, the risk of pancreatic cancer increased among male alcohol drinking groups, and the OR was 1 7(95%CI: 1 3～2 3). BMI of patients was significantly higher than that of controls in male( P =0 005), but there was no significant difference in female( P =0 092). The results suggested that smoking, heavy alcohol consumption and BMI in male were risk factors of pancreatic cancer, whereas smoking was the only independent factor.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第4期289-291,共3页
Medical Journal of Chinese People's Liberation Army
基金
全军首批临床重大技术资助项目
