摘要
以 5 -氟尿嘧啶为原料经硅醚化、和四乙酰核糖缩合、皂化、酮缩醇形成、碘化、氢解及水解等反应合成了去氧氟尿苷。本法工艺简便、条件缓和、原料易得、成本低 ,总收率达 5 4.6 %
Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2002年第3期108-110,共3页
Chinese Journal of Pharmaceuticals
