摘要
采用 IL ISA法测定了哮喘发作期和缓解期患儿的血清白介素 - 12 ( IL- 12 )和白介素 - 4 ( IL- 4 )。结果发现 ,发作期哮喘患儿 IL - 12水平 ( 3 5 .2± 11.18pg/ ml)显著低于缓解期 ( 4 2 .75± 13 .3 8pg/ ml)和健康儿 ( 4 5 .4 3±2 9.19pg/ ml) ,P分别 <0 .0 1、0 .0 5。发作期和缓解期哮喘患儿血清 IL - 4阳性率 (分别为 5 5 .5 6%和 3 6.3 6% )均显著高于健康儿 ( 9.1% ) ,P分别 <0 .0 1、0 .0 5。IL- 12和 IL- 4呈显著负相关 ( r=- 0 .3 4 ,P<0 .0 5 )。认为哮喘患儿存在明显的 Th1 / Th2 类细胞因子失衡 ,IL- 12和 IL- 4在哮喘发病中都起重要作用。吸入糖皮质激素等治疗可改变这种失衡状态。
IL 12 and IL 4 of 36 asthmatic children in acute stage and 22 in relief stage were tested by ELISA Results showed the Level of IL 12 of the children in acute stage(35 12±11 18pg/ml)was remarkably lower than both of those in relief stage(42 75±13 38pg/ml)and those healthy ones (45 43±29 19pg/ml) Positive rate of IL 4 of the children both in acute(55 50%)and relief(36 36%)stage was higher than that of healthy ones Its were negatively corre lated(γ s=-0 34,P<0 05) This suggest that,there is magnificent disbalance of the Th 1/Th 2 existing in asthmatic childnen IL 12 and IL 4 have vital function in the process of asthma Breathing in glucosteroid hormone and other officient agent can correct this disbalance
出处
《山东医药》
CAS
北大核心
2002年第5期21-22,共2页
Shandong Medical Journal
