摘要
目的 评价哌拉西林 /他唑巴坦防治烧伤感染的疗效。 方法 选择脓毒症或烧伤总面积大于 5 0 %TBSA或Ⅲ度烧伤面积大于 30 %TBSA的脓毒症高危患者 6 3例。给药方案为 ,治疗脓毒症剂量 4 .5g ,1次 /6～ 8h ;预防性治疗剂量 4 .5g ,1次 /8h。静脉给药。脓毒症状完全消失或局部创面感染未发展成脓毒症为有效。 结果 总有效率为 90 .4 % ,控制脓毒症有效率为 75 % ,预防局部创面感染发展成脓毒症有效率为 95 .7%。治疗组和预防性治疗组细菌清除率分别为 71.4 %和5 1 4 %。 结论 在烧伤中心 ,哌拉西林 /他唑巴坦是治疗病原菌敏感的脓毒症和预防性治疗经验性用药的有效抗生素。
Objective To evaluate the efficacy of piperacillin/tazobactam in the management of burn infection. Methods Sixtythree burn patients were enrolled in the study with burn sepsis or burn area more than 50%TBSA or full skin loss more than 30% TBSA. The administration regime of the antibiotics was 4.5g intravenously administered every 8 hours in the treatment of burn sepsis or in the prophylactic management. The effectiveness was identified when the septic symptoms disappeared or focal infection did not develop into sepsis. Results The overall clinical efficacy was 90.4%,and success in sepsis (control) was 75%. Furthermore, 95.7% of the focal infection was prevented from developing into systemic infection. The bacterial clearance rates were 71.4% and 51.4% in treatment and prophylaxis groups, respectively. Conclusion Piperacillin/taxobactam was effective in the treatment and/or prophylaxis of burn sepsis caused by bacteria susceptible to it, so it could be applied empirically. [
出处
《中华烧伤杂志》
CAS
CSCD
2002年第2期75-77,共3页
Chinese Journal of Burns
