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Egr-1在小鼠和人组织中的表达及其与细胞增殖的关系 被引量：3

Egr-1 EXPRESSION IN MOUSE AND HUMAN TISSUES AND ITS RELATION TO CELL PROLIFERATION
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摘要 目的　探讨早期生长反应基因 - 1(Egr- 1)在小鼠和人体组织和细胞中的表达及其与细胞增殖的联系。方法　应用原位杂交和免疫组织化学法对小鼠和人的不同组织进行 Egr- 1检测。结果　 Egr- 1m RNA和 Egr- 1蛋白阳性信号呈棕褐色 ,位于细胞浆和细胞核。生长活跃和增生的细胞可见相对高水平的 Egr- 1表达。结论　 Egr- 1m RNA和 Egr- 1蛋白的高表达主要在生长活跃和增生的细胞 ,与细胞增殖有密切的关系。 ? Objective To study the expression of early growth response gene 1(Egr 1) in mouse and human tissues and its relation to cell proliferation. Methods In situ hybridization and immunohistochemistry were respectively used to demonstrate Egr 1mRNA and its protein product in different tissues of mouse and human. Results Egr 1mRNA and Egr 1 protein positive signals were brown in colour and located in the cytoplasm and nucleus. Egr 1 expression showed relatively high level in actively growing cells and proliferative cells. Conclusion There is a close relationship between the high expression Egr 1 and cell proliferation.\;〔
作者 吴名耀 庄楚香
机构地区 汕头大学医学院病理学教研室 汕头大学医学院生理学教研室
出处 《中国组织化学与细胞化学杂志》 CAS CSCD 2002年第1期72-74,118,共4页 Chinese Journal of Histochemistry and Cytochemistry
基金 国家自然科学基金资助 (No. 396 70 2 98)
关键词 EGR-1 细胞增殖 原位杂交 免疫组织化学 小鼠人 表达 Egr-1 Cell proliferation In situ hybridization Immunohistochemistry Mice Human
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

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同被引文献34

  • 1段佑才,姜泊,马高峰,徐智民,陈晓文,程天明,戴益琛,陈学清.Egr-1基因剔除减少炎性相关因子在实验性胰腺炎中的表达[J].中国病理生理杂志,2007,23(4):739-743. 被引量：5
  • 2Cao XM, Koski RA, Gashler A, et al. Identification and characterization of the Egr-1 gene produet, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol,1990,5:1931-1939.
  • 3Huang RP, Fan Y,de Belle I, et al. Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation. Int J Cancer, 1997,72:102-109.
  • 4Mitchell A, Dass CR, Sun LQ, et al. Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1. Nucleic Acids Res ,2004 ,32 :3065-3069.
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  • 6Shozu M,Murakami K, Segawa T, et al. Decreased expression of early growth response-1 and its role in uterine leiomyoma growth. Cancer Research,2004,64:4677-4684.
  • 7Liu C,Adamson E, Mercola D. Transcription factor Egr-1 suppresses the growth and transformation of human HT 1080 fibrosarcoma cells by induction of tranforming growth factor betal. Proc Natl Acad Scj USA. 1996,93:11831-11836.
  • 8Mom GR, Olivier KR, Cheville JC, et al. The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate. Molecular Cancer Research ,2004,2 : 115 -128.
  • 9Baron V, Aden ED, Calogero A, et al. The transcription factor Egrl is a direct regulator of multiple tumor suppressors including TGFbetal, PTEN,p53,and fibronectin. Cancer Gene Ther,2006, 13:115-124.
  • 10Baron V, De Gregorio G, Krones-Henaig A, et al. Inhibition of Egrl expression reverses transformation of prostate cancer cells in vitro and in vivo. Oncogene ,2003 ,22 :4194-4204.

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中国组织化学与细胞化学杂志
2002年 第1期

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