摘要
目的:研究脑泰方对气虚血瘀型脑梗死患者血清肿瘤坏死因子(TNF-α)及血浆血栓素B2(TXB2)和6-酮-前列腺素F1α(6-Keto-PGF1α)含量的影响,进一步探讨脑泰方治疗气虚血瘀型脑梗死的有效作用机制,为其临床应用提供理论依据。方法:利用放免法检测36例气虚血瘀型脑梗死患者用脑泰方前后血清TNF-α及血浆TXB2、6-Keto-PGF1α的含量,并与36例未用脑泰方的气虚血瘀型脑梗死患者进行对照。结果:用药3周后,治疗组降低血清TNF-α及血浆TXB2含量和升高血浆6-Keto-PGF1α的含量较对照组明显(P<0.05)。结论:脑泰方治疗气虚血瘀型脑梗死的疗效机理与其具有降低患者血清中增高的TNF-α含量及调节血管内皮/血小板功能平衡有关,且优于尼莫地平。
Objective:In order to research the mechanisms of Naotaifang in treating cerebral infarction with difficiency of Qi and blood stasis, tumor necrosis factor (TNF-α) in serum and TXB2 and 6-Keto-PGF1α in plasma of the patients were detected. Method:72 patients with cerebral infarction with difficiency of Qi and blood stasis were randomly divided in treating group (36 cases) and control group (36 cases), individually taking orally or nasal feeding Naotaifang and Nimoldipine. TNF-α in serum and TXB2 and 6-Keto-PGF1α in plasma were detected by using RIA. Results: After 3 weeks, TNF-α in serum and TXB2 in plasma were significantly lower and 6-Keto-PGF1α in plasma were markedly higher than that of control (P<0.05). Conclusion:The mechanisms of Naotaifang in Treating cerebral infarction with difficiency of Qi and blood stasis might be that it decreased the contents of increased TNF-αand adjusted the function balance of vascular endothelium and platelet.
出处
《中国中医药信息杂志》
CAS
CSCD
2002年第4期16-17,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
脑梗死
脑泰方
气虚血瘀证
尼莫地平
治疗
cerebral infarction
Naotaifang
difficiency of Qi and blood stasis
nimoldipine
