摘要
目的 对亚慢性镉中毒大鼠的肾组织进行超微结构检查。方法 SD大鼠腹腔注射0.8mg·kg^(-1)·d^(-1)CdCl_2溶液(相当于0.8mgCd^(2+)),每周5次,共4周。取肾组织常规制片,透射电镜下观察。结果 镉中毒大鼠肾近曲小管上皮细胞、线粒体肿胀,嵴断裂,肾小球系膜细胞增生,足突间隙融合,鲍曼氏囊腔狭窄、毛细血管瘀血及间质纤维化,肾远曲小管上皮细胞肿胀、崩解,线粒体水肿、膜破裂。结论 亚慢性镉染毒除引起肾近曲小管上皮细胞出现超微结构病理改变外,对肾小球和肾远曲小管上皮细胞也产生严重损害。
[Objective]To make ultrastructural examination on renal tissues in rats with sub- chronic cadmium intoxication. [Methods]SD Rats were injected with 0.8 mg. Kg-1 .d - 1Cd DI2 (equals to 0.8mgDd2 + ) into abdominal cavity. Renal tissues were examined by transmission electron microscopy . [Results]Swollen cytoplasm and mitochondria as well as broken spinal were seen in proximal tubular lining cells. Mesangium cell hyperplasia, sub- podocytic space confluence, Bowman s capsule narrowing, capillary blood stasis, interstitial fibrosis occurred in renal glomeruli. In distal tubular lining cells, the cell swelled and disintegrated, mitochondria swelled and membrane broke down. [Conclusion] Sub- chronic cadmium exposure not only induced pathological ultrastructural changes in renal proximal tubular lining cells, but also exerted serious lesions on glomerulus and distal tubular lining cells.
出处
《职业与健康》
CAS
2002年第5期3-5,共3页
Occupation and Health
关键词
大鼠
亚慢性镉中毒
肾组织
超微结构
Sub- chronic cadmium intoxication, Renal tissue, Ultrastructure
