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白细胞介素-18与肾脏疾病 被引量：2

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摘要 白细胞介素（ＩＬ）－１８主要由单核巨噬细胞产生，主要诱导产生γ干扰素，对Ｔ细胞、Ｂ细胞、ＮＫ细胞、巨噬细胞均有调节作用。ＩＬ－１８能加重实验性缺血性急性肾功能衰竭的肾损害，肾病综合征患者外周血单个核细胞分泌ＩＬ－１８增加，在新月体肾炎和系统性红斑狼疮的极期，血中ＩＬ－１８水平高于恢复期和正常对照组，表明ＩＬ－１８与它们的发病有密切关系。
作者 卢宏柱
机构地区 武汉大学人民医院儿科
出处 《国外医学（儿科学分册）》 2002年第2期100-102,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 白细胞介素18 细胞活素类 肾疾病 生物学特征
分类号 R692.02 [医药卫生—泌尿科学]
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参考文献20

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同被引文献20

  • 1易著文,党西强.重视儿童继发性肾损害的临床研究[J].临床儿科杂志,2006,24(4):243-245. 被引量：8
  • 2Taber SS, Pasko DA. The epidemiology of drug-induced disorders: the kidney. Expert Opin Drug Saf,2008, 7(6) :679-690.
  • 3Patzer L. Nephrotoxicity as a cause of acute kidney injury in chil- dren. Pediatr Nephrol, 2008,23(12) :2159-2173.
  • 4Palmer BF. Renal dysfunction complicating the treatment of hyper- tension. N Engl J Meal,2002,347 (16) :1256-1261.
  • 5Schoolwerth AC, Sica DA,Ballermann B J, et al, Renal considerations in angiotensin converting enzyme inhibitor therapy:a statement for healthcare professionals from the Council on the Kidney in Cardio- vascular Disease and the Council for High Blood Pressure Research of the American Heart Association. Circulation, 2001,104 ( 16 ) : 1985-1991.
  • 6Wiik A. Clinical and laboratory characteristics of drug-induced vas- culitic syndromes. Arthritis Res Ther,2005,7 (5) : 191-192.
  • 7Lamas S. Cellular mechanisms of vascular injury mediated by calci- neurin inhibitors. Kidney Int ,2005,68 (2) :898007.
  • 8Scherrer U,Vissing SF,Morgan B J, et al. Cyclosporine-induced sym- pathetic activation and hypertension after heart transplantation. N Engl J Med, 1990,323 (11 ) :693-699.
  • 9Piera-Velazquez S, Li Z, Jimenez SA. Role of endothelial-mesenchy- mal transition(EndoMT) in the pathogenesis of fibrotic disorders. Am J Patho1,2011,179 ( 3 ) : 1074-1080.
  • 10Markowitz GS ,Perazella MA. Drug-induced renal failure:a focus on tubulointerstitial disease. Clin Chim Acta,2005,351 ( 1-2 ) :31-47.

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国外医学（儿科学分册）
2002年 第2期

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