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应用静脉糖耐量试验评价胰岛移植疗效的实验研究

Experimental study on islands of langerhans transplantation by IVGTT
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摘要 目的 对胰岛移植在维持受体内糖代谢稳定方面的能力进行评价。方法 应用静脉糖耐量试验。结果 胰岛移植物在受体内对葡萄糖刺激具有良好的反应 ,其胰岛素的分泌接近于正常胰腺糖负荷后胰岛素的生理分泌模式 ,胰岛移植可以有效地维持受体内糖代谢的稳定。结论 胰岛移植是治疗 Objective To evaluate the effects of islands of langerhans transplantation on maintaining glucose metabolism stability in recipients. Methods Intravenously glucose tolerance test (IVGTT) was used. Results The allografts had better reaction to the stimulation of glucose, and the product of insulin was adjacent to the physiological secretion of normal pancreas after glucose loaded.The islets of langerhans transplantation could effectively maintain glucose metabolism stability in recipients. Conclusion Islands of langerhans transplantation was a realistic method to therapy type 1 diabetes.
出处 《哈尔滨医科大学学报》 CAS 2002年第2期135-137,共3页 Journal of Harbin Medical University
关键词 静脉糖耐量试验 评价 胰岛移植 实验研究 IVGTT IVGTT transplantation of islands of langerhans theraputic effects
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参考文献4

  • 1Sutton R, Peters M, McShane P,et al. Isolation of rat pancreatic islets by ductal injection of collagenase[J].Transplantation,1986,42:689-691.
  • 2Shewade YM,Umrani M,Bhonde RR.Large-scale isolation of islets by tissue culture of adult mouse pancreas[J].Transplant Proc,1999,31:1721-1723.
  • 3Munn SR, Kaufman DB, Field MJ, et al. Successful 24 and 48h cold storage of the pancreas prior to islet isolation and transplantation[J].TransplantProc,1989,21:2635-2637.
  • 4Marchetti P,Olack B,Swanson C,et al.Assessment of long-term(1 year) graft survival and metabolic and hormonal changes after intrasplenic canine pancreatic microfragment transplantation[J].Diabete Meteb,1993,19:17-24.

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