摘要
目的 探讨p53蛋白增殖细胞核抗原 (PCNA)在乳腺浸润性导管癌中的表达及预后的关系。方法 应用免疫细胞ABC法对乳腺癌p53和PCNA的表达进行检测。结果 死亡组p53蛋白阳性表达率 (94 2 8% ,33/ 35)和PCNA指数 (PI) (55 .5 %± 2 5 .47% )明显高于存活组的p53蛋白阳性表达率 (46 .1 5 % ,30 / 65)和PI(30 .8%±2 0 .0 8% )。临床分期和淋巴结转移有显著关系。结论 p53蛋白与PCNA间有显著的正相关 。
Objective To investigate the relationship between p53 and proliferating cell nuclear antigen(PCNA) expression in breast invasive ductal carcinoma and their significance in prognosis.Methods The expression of p53 and PCNA was defected in breast invasive ductal carcinoma by immunohistochemical ABC method.Results The positive rate of p53 expression and PCNA index(PI) were significantly higher in the dead patients than in surviving patients.p53 positive and PCNA were 94.28% and 55.5%±25.47% respectively in dead cases.The expression of p53 and PCNA was apparently correlated with lymph node metastasis and clinical staging.Conclusion Expression of p53 are positively correlated with PI.These two markers combined may be used as an important indicator of prognosis in breast carcinoma.
出处
《哈尔滨医科大学学报》
CAS
2002年第2期131-132,共2页
Journal of Harbin Medical University
