摘要
目的 :研究血清白蛋白含量在肝纤维化形成过程中的变化。方法 :用四氯化碳 (CCl4)诱发鼠肝纤维化模型 ,测定CCl4处理前及处理后 2、4、6、8周血清白蛋白及肝脏胶原蛋白含量。结果 :血清白蛋白含量在CCl4处理后 2周明显降低 ,随后开始增加 ,到第 8周时又出现下降 ;肝脏胶原蛋白含量在第 2周明显增加 ,并一直保持不变。结论
Objective:To observe the change of serum albumin in live fibrosis. Metheds: Rat liver fibrosis was induced by CCl *#4.The contents of serum albumin and liver collagen were measured in 2?4?6 and 8 weeks after treatment. Results: The contents of serum albumin decreased and Hepatic collagen increased singnificantly in two weeks after treatment, then ,the serum albumin increased ,but decreasd again at the 8 th week.Hepatic collagen kept the same level at the 4 th ,6 th ,and 8 th weeks post-treatment. Conclusions: The serum albumin levels might be an good indicator of early liver fibrosis and its prognosis.
出处
《贵阳医学院学报》
CAS
2002年第2期128-129,共2页
Journal of Guiyang Medical College
