摘要
目的 探讨重症胰腺炎的发病机制.方法 胆胰管内逆行加压注射3.5%的牛磺胆酸钠复制大鼠胰腺炎模型,分别经腹主动脉及外周静脉灌注改善微循环药物,用活体显微镜及连续录像摄影观察胰腺等脏器的微循环和病理改变.结果 经腹主动脉灌注较外周静脉灌注药物微循环及病理变化改善显著.结论 胰腺等脏器的微循障碍是重症胰腺炎的始动因素,又是恶化因素.早期经腹主动脉灌注改善微循环药物,可防止重症胰腺炎发展.
[ABSTRACT] Objective:To study of pathogenesis of acute severe pancreatitis (ASP). Methods: Minic models of rats with ASP were replieated. Retrograde inject 3.596 sodium traurodeoxideocholic acid into them via pancreatic-bile duct with the catheters to abdominal aorta and peripheral blood vessel was performed. Then the changes of pancreatic morphology were observed by macroscopy and microscopy and microcirculation was observed by intravital microscopy. Results:By abdominal aorta perfusion there was significant difference in the changes of pancreatic pathomorphology and microcirculation between abdominal aorta perfusion and peripheral perfusion. Conclusion : The obstacle of pancreatic microcirculation makes ASP start and worsen and therefore the early use of drugs of improving microcirculation by abdominal aorta perfusion can prevent ASP from worsening.
出处
《中国现代普通外科进展》
CAS
1999年第4期28-30,共3页
Chinese Journal of Current Advances in General Surgery
基金
云南省跨世纪人才培养基金资助项目(97C027G)
关键词
胰腺炎
微循环
导管插入术
运动实验
灌注药物
Pancreatitis
Microcirculation
Catheterization, peripheral
Rats, inPred strains
