摘要
目的 :探讨不同性别对西布曲明片减肥疗效的影响。方法 :男、女性受试者各 2 2例 ,口服西布曲明 10mg·d- 1× 6wk。比较 2组治疗前后体重差百分比、腰围、臀围、腰围差值、臀围差值、腰臀围比(WHR)、BMI差值 ( BMI)及血糖、血脂等指标。结果 :女、男性组体重差百分比治疗后 2 ,4 ,6wk分别为 - 2 .1± 1.8,- 2 .9± 1.6,- 4.4± 2 .1,和 - 1.1± 0 .9,- 1.8± 1.1,- 2 .9± 1.4 (P <0 .0 5 ) ; BMI2 ,4 ,6wk女、男性组分别为 - 0 .7± 0 .6,- 0 .9±0 .5 ,- 1.4± 0 .7和 - 0 .35± 0 .2 8,- 0 .6± 0 .3,- 0 .9± 0 .5 ,P <0 .0 5 ;6wk女、男性组腰围分别为(87± 2 1)cm ,(98± 9)cm ,(P <0 .0 5 ) ;WHR、空腹血糖 6wk女性组较男性组均下降明显。结论 :女性组对西布曲明片减肥效果较男性组更为明显。
AIM: To explore the effect of sibutramine on weight loss between female and male overweight or obesity patients. METHODS: Twenty two female and Twenty two male overweight or obesity patients orally received sibutramine 10 mg·qd for 6 wk. Then changes of percent of weight difference, waistline, hipline, waist hip ratio (WHR),body mass index(BMI),BMI difference(BMI), blood glucose ,blood lipid were compared. RESULTS: Compared with male group, percent of weight difference of female group decreased more significantly at 2,4,6 wk ( P < 0.05). The percent of weight difference were -2.1±1.8,-2.9±1.6 and -4.4±2.1 in female group ,while -1.1±0.9,-1.8±1.1 and -2.9±1.4 in male group. BMI difference decreased at 2,4,6 wk( P <0.05). The BMI were -0.7±0.6,-0.9±0.5,-1.4±0.7 in female group while -0.35±0.28,-0.6±0.3,-0.9±0.5 in male group; waist and WHR of female group (87±21) cm,0.82±0.18 falled more obviously than that of male group (98±9)cm,0.92±0.09 at 6 wk ( P <0.05). The fasting blood glucose decreased at 6 wk( P <0.05). CONCLUSION: The preliminary result suggests that the effect of sibutramine on weight loss of female overweight or obesity patients is higher than that of male group.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第4期234-236,共3页
Chinese Journal of New Drugs and Clinical Remedies
