摘要
目的 :观察赛莱乐治疗对多梗死性痴呆 (MID)患者CD6 2 P、CD6 3、P10 、DI变化的影响。方法 :将禁用阿司匹林及尼莫地平的 78例MID患者分 2组 ,治疗组 4 8例 ,应用赛莱乐 15 0mg静滴 ,1次 /日× 15天 ;对照组 30例 ,复方丹参 2 0ml静滴 ,1次 /日× 15天 ,观测治疗前、后CD6 2 P、CD6 3、P10 及DI变化。结果 :治疗后治疗组CD6 2 P、CD6 3、P10表达明显降低 ,DI明显增强 (P <0 0 1)与对照组比差异显著 (P <0 0 5 )。CD6 2 、P10 与DI呈负相关 (P <0 0 5 ) ,CD6 3与DI无相关。结论 :赛莱乐可降低CD6 2 P、CD6 3、P10 表达 ,抑制血小板活化 ,增强红细胞变形能力 ,对MID恢复有益。
Objective:To observe the effects of buflomedil hydrochloride injection on CD 62 P,CD 63 ,P 10 ,DI alteration in multiple infarction dementia(MID) patients.Methods:78 patients with multiple infarction dementia who were inhibited with Aspirin and Nimodipine were divided into two groups:48 patients in therapy group received the Buflomedil Hydrochloride injection by intravenous infusion with 150mg/day for 15 days,while the rest in control group treated with an experimental compound Danshen by intravenous infusion with 20ml/day for 15 days. The alteration of CD 62 P,CD 63 ,P 10 ,DI before and after therapy were observed.Results:After 15-day treatment,the express in therapy group of DI enhanced according to the decline of CD 62 P,P 10 (P<0 01),which was inverse ratio(P<0 05).It had a greater difference than that in the control group(P<0 05).But,it showed no pronounced relation in the express of CD 63 and DI.Conclusion:Buflomedil Hydrochloride could decrease the express of CD 62 P,CD 63 ,P 10 ,inhibit platelet activation,enhance red blood cell deform ability,show a great benefit on the recovery of multiple infarction dementia patients.
出处
《河南实用神经疾病杂志》
2002年第3期3-4,共2页
Henan Journal of Practical Nervous Diseases
