摘要
研究了三莪二金汤的利尿、溶石作用及其急性毒性。按交叉实验设计法给家兔灌胃40％煎剂50ml/kg,药后3和10h的累积尿量分别增加59.4％(P<0.05)和31.5(P<0.01)。用65％煎剂浸泡临床尿石标本,对主要含有尿酸、胱氨酸或磷酸钙的结石呈现溶解或裂解作用。分别用1200％、600％煎剂和生理盐水1.2ml/10g给小鼠灌胃,7日内均无死亡,生长和活动均未见异常。
The diuretic and urolith dissolving effects and acute toxicity of decoction of Sane Erjin Tang were investigated. When 40% decoction (50ml/kg)was taken intragastrically in 10 rabbits with cross-over desigh,the accumulative volume of urine during 3 and 10 hours were increased by 59.4% (P<0. 05)and 31. 50% (P<0. 0 1 )respectively. The dissolving or splitting ef- fects on the urolithic specimens mainly containing uric acid, cystinic acid or calcium phosphate were seen when they were steaped in 65% decoction. The acute toxicicy of the decoction was also studied preliminarily in the experiment.
出处
《泰山医学院学报》
CAS
1991年第4期346-350,共5页
Journal of Taishan Medical College
关键词
三莪二金汤
药理
毒性
Sane Erjin Tang
Pharmacological effects
Acute toxicity
