摘要
目的 :提高对原发性中枢神经系统恶性淋巴瘤 (PCNSL)临床特征的认识。方法 :回顾性分析经病理证实的 5 4例PCNSL。结果 :该肿瘤多发生于中老年患者 ,性别无明显差异 ;好发于幕上 ,临床上无特征性表现。5 4例中获随访 4 9例。随诊期 3～ 14 3个月 ,平均 31个月 ,中位数为 2 0个月。其中EERC、PRRC、XC、RC、ST五组的中位生存时间分别为 2 2、 19、 2 1、 17、 9个月。其中EERC、PRRC、XC、RC四组间差异无显著性 (P均 >0 5 ) ,ST组同其他四组对数秩检验差异显著 (P均 <0 0 5 )。结论 :原发性中枢神经系统恶性淋巴瘤术前难以确诊 ,预后不良。手术的主要目的是解除肿瘤引起的颅内高压 ,减轻或解除脑神经功能的进一步废损 ,明确诊断。强调术后常规放疗和化疗 。
Objective:To have a better understanding of the clinical characteristics of primary central nervous system lymphoma(PCNSL).Methods∶The clinical data of 54 patients with PCNSL were studied retrospectively.Results∶PCNSLs ofen occurred in adults and aged patients, no signifi cant difference in sex;and the majority of PCNSLs were found in supratentorial reg ion of cranial cavity.Forty-nine of 54 cases were followed up,28 cases are still alive and 5 cases were missing.The time of follow-up was from 3 to 143 months,the averag e was 31 months and the median is 20 months.The mean lifetime of the group performed entire tumor excision and accepted radiotherapy and chemothe rapy(EERC) was 22 months,the group underwent partial tumor resection and received radiotherapy and chemotherapy(PRRC) was 19 months, the group had X-knife and c hemotherapy(XC) was 21 months, the group accepted radiotherapy and chemotherapy(RC) was 17 months,the group merely received surgical therapy (ST) was 9 months.No significant difference in the mean lifetime wsa observed between EERC and PRR C,EERC and XC,EERC and XC,PRRC and RC,PRRC and RC,XC and RC( P >0 05).The group between ST and EERC,PRRC XC,RC had significant relation in the mean lifetime( P <0 05).Conclusion∶It is difficult to diagnose the PCNSL before operation and the prognosis of this disease is poor. T he main objective of surgical therapy is to relieve the intracranial hypertension and the further damage to cranial nerve function caused by the tumor and darity t he final di agnosis.Emphasizing regular poctopeictive radiotherapy and chemotherapy;wa s the crux of prolongation of the liftime and improvement of the qualit y of life.
出处
《华西医学》
CAS
2002年第1期19-21,共3页
West China Medical Journal
关键词
淋巴瘤
脑肿瘤
手术治疗
放疗
化疗
s:lymphoma
brain tumor
surgical therapy
radiotherapy
chemotherapy
