摘要
目的 :研究检测解脲脲原体 (Uu)临床株对氟喹诺酮类药物的敏感性 ,为临床治疗提供参考依据。方法∶应用微量肉汤稀释法检测了 88株Uu对 6种氟喹诺酮类药物的敏感性。结果∶在 6种药物中司帕沙星和加替沙星抗Uu活性最强 ,MIC50分别为 0 .2 5 μg/ml和 0 .5 μg/ml,MIC90 均为 4μg/ml。其次为左氧氟沙星和氧氟沙星 ,MIC50 分别为 1μg/ml和 2 μg/ml,MIC90 分别为 4μg/ml和 8μg/ml。诺氟沙星和环丙沙星的抗Uu活性最差。 结论∶氟喹诺酮类抗菌药新品种司帕沙星、左氧氟沙星和加替沙星的抗Uu活性较老一代药物更强 ;
Objective: To determine the susceptibility of clinical Ureaplasma urealyticum (Uu) isolates to fluoroquinolones and provide experimental data for clinical therapy. Methods:Broth microdilution method was used for susceptibility testing of 88 isolates of Uu to 6 fluoroquinolones. Results:Among 6 fluoroquinolones, sparfloxacin and gatifloxacin were the most active agents against Uu, MIC 50 being 0.25μg/ml and 0.5μg/ml, respectively; with MIC 90 being 4μg/ml for both. Levofloxacin and ofloxacin were less active, MIC 50 being 1μg/ml, 2μg/ml and MIC 90 being 4μg/ml, 8μg/ml, respectively. Norfloxacin and Ciprofloxacin had the least activity against Uu. Conclusions: New fluoroquinolones such as sparfloxacin, levofloxacin and gatifloxacin show greater activity against Uu than the older agents do; Uu is resistant to older fluoroquinolones in varing degree.
出处
《中国抗感染化疗杂志》
2002年第1期17-19,共3页
Chinese Journal of Infection and Chemotherapy
基金
湖南省教委重点资助项目 (No .0 0A0 0 9)
关键词
解脲脲原体
抗感染制剂
氟喹诺酮类药物
药物敏感性试验
最低抑菌浓度
Ureaplasma urealyticum
Anti infective agents
Fluoroquinolone
Antimicrobial sensitivity tests
Minimum inhibitory concentration
