摘要
目的 探讨CT引导^(125)I粒子植入联合吉西他滨+顺铂(GP)治疗非小细胞肺癌(NSCLC)的临床疗效。 方法 将2013年1月至2017年1月间62例Ⅱb~Ⅲb期不可切除的NSCLC患者按照随机数字表法分成2组,研究组[32例;男17例,女15例;年龄(62.7±8.9)岁]行^(125)I粒子植入联合GP方案4个疗程化疗,对照组[30例;男18例,女12例;年龄(61.9±7.0)岁]行同步放疗联合GP方案4个疗程化疗。对比分析2组患者治疗3和6个月后的近期疗效,并对生存时间进行比较。采用log-rank检验分析数据。 结果 研究组和对照组治疗3和6个月后有效率分别为90.62%(29/32)、70.00%(21/30)和96.88%(31/32)、66.67%(20/30),差异均有统计学意义(χ^(2)值:3.00和7.22,均P<0.05);2组患者的中位生存时间分别为17和15个月(χ^(2)=2.194,P>0.05)。研究组与对照组患者的1年生存率未见明显差异[87.50%(28/32)和76.67%(23/30);χ^(2)=1.24,P>0.05];2年生存率的差异有统计学意义[40.62%(13/32)和20.00%(6/30);χ^(2)=4.00,P<0.05]。 结论 ^(125)I粒子植入联合GP方案化疗治疗不可切除NSCLC的近期疗效优于同步放疗联合GP方案。
Objective To investigate the clinical efficacy of CT-guided^(125)I seeds implantation combined with gemcitabine+cis-platinum(GP)in the treatment of unresectable non-small cell lung cancer(NSCLC).Methods From January 2013 to January 2017,62 patients with unresectableⅡb-Ⅲb NSCLC were randomly divided into 2 groups.In the study group,32 patients(17 males,15 females,age(62.7±8.9)years)underwent^(125)I seeds implantation combined with 4 courses of GP chemotherapy,and 30 patients(18 males,12 females,age(61.9±7.0)years)in the control group underwent concurrent radiotherapy combined with 4 courses of GP chemotherapy.The short-term effects at 3 and 6 months after treatment were compared between 2 groups,as well as the survival time.Log-rank test was used to analyze the data.Results The effective rates at 3 and 6 months after treatment in the study group and control group were statistically significant(90.62%(29/32)vs 70.00%(21/30),96.88%(31/32)vs 66.67%(20/30);χ^(2) values:3.00 and 7.22,both P<0.05).The median survival time of the study group and control group were 17 and 15 months(χ^(2)=2.194,P>0.05).The 1-year survival rates of 2 groups were 87.50%(28/32)and 76.67%(23/30),respectively(χ^(2)=1.24,P>0.05),and the 2-year survival rates were 40.62%(13/32)and 20.00%(6/30),respectively(χ^(2)=4.00,P<0.05).Conclusions^(125)I seeds implantation combined with GP chemotherapy is a significant treatment for unresectable NSCLC.The short-term efficacy is better than concurrent radiotherapy combined with GP regimen.
作者
邹佳丽
陆武
陈鹏
宋长祥
刘永
袁小帅
杜鹏
Zou Jiali;Lu Wu;Chen Peng;Song Changxiang;Liu Yong;Yuan Xiaoshuai;Du Peng
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2019年第2期96-99,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
江苏省人力资源与社会保障厅“六大人才高峰”资助项目(2013-WSW-012).
