摘要
逆流色谱是一种连续高效的液-液分配色谱技术,近年来已广泛应用于天然产物、合成产物中目标成分的分离纯化,在异构体分子的制备分离中也发挥了一定优势。本文以异构体类型分类总结,总结了近年来逆流色谱在构造异构体、立体异构体等异构体分子分离中的应用研究进展。
Countercurrent chromatography belongs to liquid-liquid partition chromatographic technique using no solid support and it has been widely applied in separation of components from natural products and synthetic mixtures,it also has an advantage in the separation and preparation of isomers.The applications of countercurrent chromatography in the separation of structural isomers and stereoisomers are reviewed in this paper according to the classification of isomers.
作者
孙文宇
王超越
张慧
楚楚
童胜强
SUN Wen-yu;WANG Chao-yue;ZHANG Hui;CHU Chu;TONG Sheng-qiang(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310032,China)
出处
《药物分析杂志》
CAS
CSCD
北大核心
2019年第1期94-104,共11页
Chinese Journal of Pharmaceutical Analysis
关键词
逆流色谱
构造异构体
立体异构体
异构体分离
研究进展
countercurrent chromatography
structural isomer
stereoisomers
isomer separation
research progress
