摘要
为了更深刻地了解耳蜗毛细胞活动的神经动力学机制,建立了基于Hodgkin-Huxley方程的毛细胞模型,通过数值模拟对不同声音频率刺激时的毛细胞膜电位、功率和能量消耗进行了神经动力学分析.研究结果表明:声音频率在0.1～20 k Hz范围内,外毛细胞膜电位的衰减低于内毛细胞,而外毛细胞功率和能量消耗的增益远高于内毛细胞.外毛细胞膜电位的低衰减、功率和能量消耗的高增益支持了外毛细胞的放大作用是由电致运动驱动的.对耳蜗毛细胞膜电位、功率和能量消耗的研究结果有助于深刻了解毛细胞活动的神经动力学性质.
To understand the neurodynamic mechanism of cochlear hair cell activity more profoundly,a hair cell model based on the Hodgkin-Huxley equation was established.Through numerical simulation,neurodynamic analysis of hair cell membrane potential,power,and energy consumption was performed.The results show that,when the sound frequency is in the range of 0.1 ~ 20 k Hz,the attenuation of outer hair cells’(OHCs) membrane potential will be lower than that of inner hair cells(IHCs),while the gains in power and energy consumption of OHCs will be much larger than those of IHCs.The lowattenuation of OHC membrane potential and the high gains in power and energy consumption support the view that the OHC amplification is driven by electromotility.The study on membrane potential,power and energy consumption of cochlear hair cell contributes to the profound understanding of the neurodynamic properties of hair cell activity.
作者
戎伟峰
王如彬
RONG Weifeng;WANG Rubin(Institute for Cognitive Neurodynamics ,School of Science, East China University of Science and Technology,Shanghai 200237,P.R.China)
出处
《应用数学和力学》
CSCD
北大核心
2019年第2期139-149,共11页
Applied Mathematics and Mechanics
基金
国家自然科学基金(11232005
11472104)~~
关键词
毛细胞
声音频率
膜电位
功率
外毛细胞放大
hair cell
sound frequency
membrane potential
power
outer hair cell amplification
