摘要
目的探讨经鼻持续气道正压通气联合牛肺表面活性剂对呼吸窘迫综合征新生儿血气指标的影响。方法将76例呼吸窘迫综合征新生儿按照随机数字表法分为研究组与对照组各38例。两组均给予常规治疗,给予经鼻持续气道正压通气治疗,研究组在此基础上联合牛肺表面活性剂治疗。比较两组临床疗效,比较两组经鼻持续气道正压通气、氧疗、住院时间,比较治疗前后两组血气指标及并发症发生率。结果研究组治疗总有效率显著高于对照组(P<0.05),经鼻持续气道正压通气、氧疗、住院时间均显著短于对照组(P<0.01)。治疗后两组二氧化碳分压水平均较治疗前显著降低(P<0.01),氧分压水平均较治疗前显著升高(P<0.01),研究组较对照组变化更显著(P<0.01)。研究组并发症发生率显著低于对照组(P<0.05)。结论经鼻持续气道正压通气联合牛肺表面活性剂治疗呼吸窘迫综合征患儿效果显著,可显著缩短患儿经鼻持续气道正压通气及氧疗时间,改善血气指标状态,安全性高。
Objective To investigate the effect of nasal continuous positive airway pressure combined with calf pulmonary surfactant on blood gas parameters in neonates with respiratory distress syndrome. Methods 76 neonates with respiratory distress syndrome were divided into study group and control group according to the random number table method. Both groups were given conventional treatment of nasal continuous positive airway pressure. The study group was combined with calf pulmonary surfactant treatment. The clinical efficacy of the two groups was compared. The nasal continuous positive airway pressure, oxygen therapy and hospitalization time were compared between the two groups. The blood gas index and complication rate of the two groups before and after treatment were compared. Results The total effective rate of the study group was significantly higher than that of the control group (P<0. 05). The nasal continuous positive airway pressure, oxygen therapy, and hospital stay were significantly shorter than those of the control group (P<0. 01). After treatment, the carbon dioxide partial pressure of the two groups was significantly lower than that before treatment (P<0. 01),and the oxygen partial pressure was significantly higher than that before treatment (P<0. 01). The study group changed more significantly than the control group (P<0. 01). The incidence of complications in the study group was significantly lower than that in the control group (P<0. 05). Conclusion Nasal continuous positive airway pressure combined with calf pulmonary surfactant for the treatment of children with respiratory distress syndrome has significant effect, which can significantly shorten the nasal continuous positive airway pressure and oxygen therapy time, improve blood gas index status, and have high safety.
作者
郭媛媛
薛伟
闫凤林
Guo Yuanyuan;Xue Wei;Yan Fenglin(Xinyang Central Hospital,Xinyang 464000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2019年第1期28-31,共4页
Journal of Clinical Psychosomatic Diseases
关键词
新生儿
呼吸窘迫综合征
经鼻持续气道正压通气
牛肺表面活性剂
血气指标
Newborn
respiratory distress syndrome
nasal continuous positive airway pressure
calf pulmonary surfactant
blood gas index
