摘要
孤独症谱系障碍(ASD)确诊主要采用现有行为学症状诊断方法,大多数ASD儿童在到了4岁左右才得到准确诊断,而此时患儿的社交障碍已经十分明显,错失了干预治疗的最佳时期。值得注意的是,国内外学者对ASD的病理机制和药物靶标进行了大量研究,越来越多结果表明胰岛素样生长因子-1(IGF-1)在ASD的发生发展中占据重要地位。本文针对IGF-1在ASD中的作用进行综述,目的是为阐明IGF-1有望成为ASD早期诊断、早期治疗的生物标志物及探讨IGF-1在ASD中的应用前景。
The diagnosis of autism spectrum disorder(ASD)is mainly dependent on behavioral symptoms,and most children could not receive accurate diagnosis until 4years old when the impairment of social interaction presents typically and the best period of intervention has been missed.It is worth noting that scientists have made a lot of theoretical and practical research on the pathological mechanism and drug target of ASD.And more and more studies have shown that the biomarker, insulin-like growth factor-1(IGF-1),plays an important role in the development and progression in ASD.This review will summarize the role of IGF-1in ASD in order to elucidate that IGF-1is expected to be a biomarker of early diagnosis and early prevention of ASD,and to explore the application of IGF-1.
作者
洪晓文
陈燕惠
HONG Xiao-wen;CHEN Yan-hui(Department of Pediatrics,Fujian Medical University Union Hospital,Fuzhou,Fujian 350001,China)
出处
《中国儿童保健杂志》
CAS
2019年第1期56-58,72,共4页
Chinese Journal of Child Health Care
