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免疫组化检测63例原发甲状腺癌中BRAF^V600E突变及其价值研究 被引量:10

Immunohistochemical detection of the BRAF^(V600E) mutation in primary thyroid carcinoma
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摘要 甲状腺乳头状癌是最为常见的甲状腺恶性肿瘤。BRAF^V600E突变是甲状腺乳头状癌中最为常见的基因突变之一。据报道,45%的甲状腺乳头状癌病例会出现BRAF^V600E基因突变。BRAF^V600E的突变对于甲状腺乳头状癌的确诊以及预测不良预后非常重要。目前可用于BRAF^V600E突变的检测方法有Sanger测序法、焦磷酸测序高分辨率熔解曲线分析及等位基因特异扩增(PCR)等方法。
作者 冯勤 李忠武 刘卉 周立新 池海谊 刘毅 FENG Qin;LI Zhong-wu;LIU Hui;ZHOU Li-xin;CHI Hai-yi;LIU Yi(Key laboratory of Carcinogenesis and Translational Research (Ministry of Education),Department of Pathology,Peking University Cancer Hospital & Institute,Beijing 100142,China)
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2018年第12期1188-1190,共3页 Chinese Journal of Practical Internal Medicine
关键词 甲状腺乳头状癌 BRAF^V600E突变 papillary thyroid carcinoma BRAF V600E mutation
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