摘要
Systemic sclerosis(SSc)is an autoimmune disease characterized by thickening of the skin and organ fibrosis.Ankylosing spondylitis(AS)is a type of arthritis with long-term inflammation of the axial joints.Previous studies presented 5 cases of concomitant AS and SSc.However,there was only 1 patient of those 5 cases complaining of muscle weakness while all patients had approximately normal creatine kinase(CK).Here we reported a young male who met the criteria for SSc and AS while showing significantly elevated CK.Human leukocyte antigen(HLA)typing results indicated the genetic susceptibility to these two diseases.The patient was prescribed prednisone(30mg/d)and cyclophosphamide.After 2 months,the patient's skin became soft with normal CK.
系统性硬化症是一种以皮肤增厚和纤维化为特征的自身免疫性疾病,强直性脊柱炎是一种以中轴关节受累为主的关节炎,强直性脊柱炎极少与弥漫性结缔组织病合并存在。既往文献报道了5例强直性脊柱炎合并系统性硬化症的病例,其中仅1例患者诉有肌无力,且5例患者的血清肌酸激酶水平均无明显异常。本文报道1例青年男性患者符合系统性硬化症与强直性脊柱炎的诊断标准,同时出现肌无力、肌酸激酶水平明显增高。人类白细胞抗原(human leukocyte antigen,HLA)分型检测发现该患者携带这两种疾病的HLA易感基因。对该患者予以强的松30 mg/d及环磷酰胺治疗,2个月后皮肤增厚好转,肌酸激酶降至正常。
出处
《中南大学学报(医学版)》
CAS
CSCD
北大核心
2018年第11期1263-1265,共3页
Journal of Central South University :Medical Science
基金
supported by the National Natural Science Foundation of China(81701621,81671622).
