摘要
目的 探讨胰岛素样生长因子 - 1(IGF - 1)对脂代谢的影响及其在高脂血症发病中的作用。方法 使用Westerndotblot杂交 ,检测了不同临床类型高脂血症患者的血清IGF - 1水平 ,并与各项血脂指标进行了相关性分析。结果 单纯高胆固醇血症 (Ⅱa型 )及单纯高甘油三酯血症 (Ⅳ型 )患者 ,其血清IGF - 1水平均明显低于健康对照组 (P <0 0 1) ,而混合型高脂血症 (Ⅱb型 )患者则与对照组没有明显差异 (P >0 0 5 ) ;所有受试对象 ,包括健康对照及高脂血症患者 ,分别考察年龄、TC、TG、HDL、LDL、ApoA、ApoB及LDL/HDL等因素与血清IGF- 1水平的相关关系 ,发现TC、TG、LDL、ApoA及LDL/HDL均与IGF - 1呈负相关。 结果 IGF - 1作为一种重要的循环内分泌多肽 ,参与脂代谢的调节。研究为阐明高脂血症的发生机制提供了一条新的线索。
Objective\ To determine the levels of insulin-like growth factor-1(IGF-1)in patients with hyperlipidemia and the effects of IGF-1 on lipid metabolism.Methods\ By Western dot blot hybridization,the levels of IGF-1 were measured in 68 patients with hyperlipidemia and 35 healthy subjects.The relationship between plasma IGF-1 and blood lipids was also observed in this study.Results\ Serum IGF-1 levels of the patients with type Ⅱa and Ⅱb decreased remarkably (P<0 001),but there was no difference between type Ⅳ and control subjects(P>0 05).Serum concentrations of IGF-1 were inversely correlated with TC?TG?LDL?ApopA and LDL/HDL in all subjects including patients with hyperlipidemia and healthy volunteers(P<0 05～0 001).Conclusion\ As an important endocrine polypeptide,IGF-1 is proved to affect the levels of lipids.Better understanding of the role that IGF-1 plays in the regulation of lipid metabolism may provide new insight into the pathogenesis of hyperlipidemia.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2002年第4期206-208,共3页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金资助项目 (编号 :395 70 2 79)
