摘要
目的 :观察葛根素、银杏黄酮等中药提取物对人血清白蛋白非酶化的影响 ;方法 :将人血清白蛋白和D ( 6 3 H )葡萄糖在 3 7℃保温 8天 ,测定3 H 葡萄糖与蛋白结合的cpm数。 结果 :葛根素、银杏黄酮对蛋白非酶糖化有不同程度的抑制作用。结论 :葛根素、银杏黄酮可能是中药治疗糖尿病慢性并发症的物质基础之一。
Purpose:This study investigated the inhibition effect of Chinese herbs extact, kakonein and gingko flavone, on the protein nonenzymatic glycosylation. [WT5”HZ]Methods: [WT5”BZ]Human serum albumin was incubated with D (6 3H)glucose at 37 for eight days and the protein nonenzymatic glycosylation was determined to study the process of the reaction as well as the effect of the incorporation of 3[KG2/3]H glucose into protein. [WT5”HZ]Results: [WT5”BZ]Results indicated that both kakonein and gingko flavone had significant inhibition effect on protein non enzymatic glycosylation. [WT5”HZ]Conclusion: [WT5”BZ]This study demonstrate that kakonein and gingko flavone are the active compounds in the Chinese herbs used in the treatment of diabetic chronic complication.
出处
《中药药理与临床》
CAS
CSCD
2000年第1期13-14,共2页
Pharmacology and Clinics of Chinese Materia Medica
