摘要
体外试验随石榴皮水提液浓度增高，ＨＢＶ病毒形态出现成团聚集、外壳缺失、核壳破裂；并剂量依赖地抑制病毒ＤＮＡ聚合酶活性；对病毒抗原抗体结合抑制的机理与特异性抗体免疫结合作用不同。提示可将石榴皮制备成阴道栓剂以预防乙肝病毒的性传播感染。
Direct killing effect of acquous extract of the Punica granatum L.(PGL) against HBV were studied in vitro. By the PGL concentration increased,(1)the virus paticles were agglutinated, the shell were lacked and the capsid were broken;(2)HBV DNA polymease was inhibited with dose depentent ralation;(3)HBV immuno combination test of antigen antibody were partly inhibited, the mechanism was different from the specific immunoreaction of antigen antibody combination. The results suggested that PGL as a vaginal suppository should have an important significance in clinic to protect against HBV sexual transmitted infection.
出处
《中药药理与临床》
CAS
CSCD
1997年第4期29-31,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家计划生育委员会基金
