摘要
为探讨高尿酸血症与冠心病之间的关系 ,对 2 0 0 9例拟诊冠心病行冠状动脉造影的患者测定禁食 12h后静脉血清尿酸值及其它生物化学指标。结果发现 ,冠心病组血清尿酸显著高于正常冠状动脉组 (36 9± 97mmol/L比 35 6± 94mmol/L ,P <0 .0 1)。单因素分析显示 ,高尿酸血症与冠心病显著相关 (χ2 MH=4 .36 4 ,P =0 .0 37,OR值为1.2 4 )。急性心肌梗死患者尿酸增高病例数较正常冠状动脉组明显增多。多因素回归分析显示血清尿酸与冠心病(χ2 wald=4 .76 ,P =0 .0 2 92 ,OR值为 0 .999)和急性心肌梗死 (χ2wald=2 3.4 8,P =0 .0 0 0 1,OR值为 1.0 0 4 )呈显著正相关。糖尿病或吸烟合并高尿酸血症时 ,OR值均明显升高。因此 ,高尿酸血症与冠心病发病显著相关 ,尤其当合并糖尿病或吸烟时该关系更为明显。
Aim To determine the relationship between hyper uricemia and coronar y artery disease (CAD). Methods Serum concentrat ion of uric acid was measured and other biochemical assessments were made at a fasting state in 2 009 patients who have undergone coronary angiography. Results S erum uric acid level was significantly higher in CAD group than in normal corona ry group(369±97 mmol/L vs. 356±94 mmol/L, P<0.01). Uni var iable analysis with Mantel Haenszel Chi test in dicated that hyperuricemia had statistically significant relation with CAD ( χ 2 MH =4.364, OR=1.24, P=0.037). Despite similar mean value of serum uric acid level between acute myocardial infarction (AMI) and nor mal coronary groups, the number of patients with abnormal serum uric acid level was greater in the former than in the latter (P<0.05). Logistic regression analysis with control of other covariables showed a significant rela tionship between plasma uric acid level and CAD (χ 2 wald =4.76, P=0.0292, OR=0.999) and AMI (χ 2 wald =23.48,P= 0.0001,OR= 1.004). Conclusions Serum uric acid level had a strong relationship with the i ncidence of CAD. This relation was further enhanced when hyperuricemia is associ ated with diabetes mellitus and cigarette smoking.
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第1期56-58,共3页
Chinese Journal of Arteriosclerosis
