摘要
目的 了解大肠埃希氏菌对氟喹诺酮类耐药性及其感染概况。方法 收集 2 0 0 0年 3月～ 2 0 0 1年 2月间华山医院大肠埃希氏菌临床分离株 ,以琼脂对倍稀释法测定细菌药敏 ,调查氟喹诺酮类耐药大肠埃希氏菌 (FREC)及氟喹诺酮类敏感大肠埃希氏菌 (FSEC)所致感染情况。结果 共分离大肠埃希氏菌 42 6株 ,FREC 2 95株 ,FSEC 131株 ,FREC对头孢菌素类、氨基糖苷类、SMZ/TMP、呋喃妥因、四环素及氯霉素的耐药性显著高于FSEC ,且大部分呈多重耐药。临床调查资料完整者 30 1例 ,共 32 0例次 ,医院感染 134例次 ,社区获得性感染 130例次 ,带菌者 5 6例次 ,其中属FREC感染 2 14例次 ,FSEC感染 10 6例次。常见感染部位均主要为泌尿道 ,次为呼吸道及胆道等部位。先前应用广谱抗菌药 ,尤其是氟喹诺酮类为FREC感染的独立危险因素。结论 大肠埃希氏菌临床分离株对氟喹诺酮类耐药性严重 ,有指征地选用氟喹诺酮类等广谱抗菌药 ,是防治FREC感染的关键。
Objective To investigate the susceptibility of Escherichia coli to fluoroquinolones and the prevalence of infections caused by Escherichia coli . Methods The isolates were collected from patients in Huashan hospital from March 2000 to Feb 2001, and tested for their susceptibility to antibacterial agents by agar dilution method. The clinical profiles of infections caused by fluoroquinolone resistant Escherichia coli (FREC) and fluoroquinolone sensitive Escherichia coli (FSEC)were investigated. Results 426 strains of Eschrichia coli were isolated, including 295 strains of FREC and 131 strains of FSEC. FREC strains were more resistant to various agents than FSEC strains, including cephlosporins, aminoglycosides, SMZ/TMP, nitrofurantoin, tetracycline and chloramphenicol. Most of FREC were multidrug resistant. 301 cases of infections caused by Escherichia coli corresponding to 320 episodes were analyzed, of which 134 episodes were nosocomial infections, 106 episodes were community acquired infections, and 56 episodes were carriers. Based on the susceptibility of Escherichia coli to fluoroquinolones, there were 214 episodes caused by FREC and 106 episodes caused by FSEC. The most common sites of infection caused by FREC or FSEC were urinary tract, followed by respiratory tract, biliary tract, and others. Prior exposure to broad spectrum antibacterial agents, especially fluoroquinolones was the independent risk factor of FREC infections. Conclusion: The high resistant rate of clinical strains of Escherichia coli to fluoroquinolones indicated the appropriate uses of fluoroquinolones and other broad spectrum antibacterial agents is critical for controlling infections caused by FREC.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2002年第3期177-180,共4页
Chinese Journal of Antibiotics
